A Paris fashion designer recently averred: “Small can be mighty.” In an era of mergers and acquisitions, outright purchases of competitors and other practices of companies striving for scale, a claim that small can be more powerful than large seems anomalous. For institutions and individuals, the question of what “right size” means for them has become crucial – larger stores and bigger ad campaigns or smaller storefronts and more subtle ad messages for businesses; larger houses and bigger cars or the reverse for consumers. In the recent past, China, Europe and the U.S., have legally challenged large corporations and their wealthy owners because they had accumulated too much power. Home buyers have been purchasing smaller new houses, and owning fewer things, while assuming less debt. But scale is not the only change that is forcing adjustments. Everyone, it seems, is making adjustments to new realities, as technological innovations, political changes and consumer shifts emerge more frequently, with greater impact, while increasing risks to those who ignore them. We have aggregated examples of these adjustments into four categories: Too Large Is Too Much; Competition Is Too Intense to Go It Alone; Supply Limits Require New Processes; and Risks Are Getting Too Pronounced to Ignore. Wave after wave of such changes.