Institutions of higher learning face a veritable wall of challenges: from political interference in academic processes to artificial intelligence’s incursion into the classroom; from a demographic cliff negatively affecting enrollment to a market demand for lower tuition; from curricula that do not fit society’s civic and employment needs to heightened global competition for the world’s best students; and from retaining top academic researchers who are losing their grants and looking overseas for funding opportunities to an expanding attitude across society that the entire college enterprise is no longer worth the time and cost. And beyond all that, these institutions’ entering students are not educationally prepared for college-level coursework. No wonder nearly three-quarters of Americans believe higher education is heading in the wrong direction. But some institutions of higher education have started to experiment with different programs, curricula, majors and structures in search of a new model of postsecondary education that can address the wall of challenges these institutions face.